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This page is intended as reference information for the general public in Great Britain.

Sayana® Press (medroxyprogesterone acetate)

What is Sayana Press and what is it used for?

Sayana Press is a contraceptive* injection and a prescription only medicine. It can be used:

  • In women, for long-term contraception; it is recommended to evaluate at least every year whether Sayana Press is still the most appropriate option in terms of risks and benefits

  • In female teenagers, but only after all other methods have been discussed with a Healthcare Professional (HCP) and they are considered unsuitable or unacceptable

The active ingredient in Sayana Press is similar to (but not the same as) the natural hormone progesterone that is produced in the ovaries during the second half of the menstrual cycle.  Sayana Press acts by preventing an egg from fully developing and being released from the ovaries during a menstrual cycle.  If an egg is not released, it cannot become fertilised by sperm and result in pregnancy.

Reference Information 

If you would like to see the Patient Information Leaflet (PIL) or Summary of Product Characteristics (SPC) for Sayana Press these can be found at the electronic Medicines Compendium (eMC).

*prevents pregnancy

Pfizer is unable to provide advice on personal medical matters. Please consult your doctor or other relevant health professional for specific, health-related advice and support.

If you get any side effects when taking this or any other medicine, talk to your doctor or other relevant health professional e.g. pharmacist, nurse. This includes any possible side effects not listed in the packaging leaflet. You can also report side effects directly via the Yellow Card Scheme at or search the Google Play or Apple App Store for MHRA Yellow Card. By reporting side effects, you can help provide more information on the safety of this medicine.

PP-SAY-GBR-0221 / February 2023
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