Depo-Medrone® with Lidocaine
(methylprednisolone, lidocaine hydrochloride)

What is Depo-Medrone with Lidocaine and what is it used for?

Depo-Medrone with Lidocaine contains methylprednisolone acetate and lidocaine hydrochloride.

Methylprednisolone belongs to a group of medicines called corticosteroids or steroids. Corticosteroids are produced naturally in your body and are important for many body functions. When injected into the body, such as in or near a joint, corticosteroids help reduce symptoms caused by inflammatory or rheumatic conditions.

This medicine also contains lidocaine which is a local anaesthetic. Lidocaine helps to reduce any local pain caused by injecting this medicine.

This medicine will be injected by a doctor or nurse to help treat the symptoms caused by the following conditions:

  • Bursitis: inflammation in the fluid containing spaces around the shoulder, knee and/or elbow joints. For this condition this medicine will be injected directly into one or more of these spaces.
  • Osteoarthritis and rheumatoid arthritis: inflammation located in between the joints. For these conditions this medicine will be injected directly into one or more joint spaces.
  • Epicondylitis, tendonitis and tenosynovitis: Tennis elbow (epicondylitis), inflammation in a tendon (tendonitis), or a tendon’s covering sheath (tenosynovitis). For these conditions this medicine will be injected into the tendon or its tendon sheath.

Health care professionals may use this medicine to treat conditions other than those listed above.

Undesirable effects may be minimised by using the lowest effective dose for the minimum period. In certain medical conditions medicines like Depo-Medrone (steroids) should not be stopped abruptly.

The medicine can only be obtained with a prescription.

Reference information

If you would like to see the Patient Information Leaflet (PIL) or Summary of Product Characteristics (SPC) for Depo-Medrone with Lidocaine these can be found at the electronic Medicines Compendium (eMC)

Pfizer is unable to provide advice on personal medical matters. Please consult your doctor or other relevant health professional for specific, health-related advice and support.

If you get any side effects when taking this or any other medicine, talk to your doctor or other relevant health professional e.g. pharmacist, nurse. This includes any possible side effects not listed in the packaging leaflet. You can also report side effects directly via the Yellow Card Scheme at or search the Google Play or Apple App Store for MHRA Yellow Card. By reporting side effects, you can help provide more information on the safety of this medicine.

 PP-DPL-GBR-0001 / October 2021